v4 Pilot Calculator UI
bug-fix
Default notation fixed
2.3.27
2026-07-24
- Default PFD notation fixed
v4 Pilot Calculator UI
update
Calculation of the SPL points modified
2.3.26
2026-07-23
- Calculation of the SPL points modified to compare the native and SPL codes as per the SVCv4 guideline
- Additional cap is introduced in the calculator for the SPL_PRD, SPL_FXN and SPL_SPA
- Calculate button is available to redo calculation and lift over the SPL values if any to the final calculation
v4 Pilot Calculator UI
bug-fix
The notation for Predicted and Functional Data fixed
2.3.23
2026-07-21
- The notation for Predicted and Functional Data was aggregating the pre-capped value; which is fixed now
v4 Pilot Calculator UI
update
CLN_AFF updated
2.3.22
2026-07-21
- CLN_AFF released for X-linked inheritance
v4 Pilot Calculator UI
update
Guidance links updated
2.3.20
2026-07-21
- Guidance links updated
- Text for DAFT calculator approach modified
v4 Pilot Calculator UI
update
Start and Stop loss fixed
2.3.19
2026-07-20
- Start and Stop loss comparison variants fixed
v4 Pilot Calculator UI
update
Phase 3 SVCv4 Pilot Launch Extended Support
2.3.17
2026-07-20
- Population Frequency feature updated
v4 Pilot Calculator UI
update
Phase 3 SVCv4 Pilot Launch Extended Support
2.3.14
2026-07-16
- Round to zero is deprecated in Phase 3
- Native score retained when the scores are same or minimum compared to the splice couterpart
- Canonical and non-canonical informative variants updated
- Feedback and Guidance documentation added
v4 Pilot Calculator UI
update
Phase 3 SVCv4 Pilot Launch
2.3.11
2026-07-14
- Phase 3 SVCv4 Pilot Launch
- Phase 2 documents are available on read-only mode
- Workflows are updated
v4 Pilot Calculator UI
update
Tool temporarily disabled
2.3.3
2026-06-01
- Tool temporarily disabled.
v4 Pilot Calculator UI
update
Workflow Update
2.3.2
2026-01-06
- Feedback forms updated.
- Set 2 and 3 variants links added.
- Bug fix with the disease allele frequency field.
- Genetic and alleleic Heterogeneity texts updated.
v4 Pilot Calculator UI
update
Workflow Update
2.3.0
2025-11-24
- Informative variant workflows updated; the first P/LP and B/LB variant fields allows 0 and 1 values.
- CLN_ALT alternate cause variant workflow updated with an additional row.
- Text updated for calculating POP_FRQ.
- Bug fix for the POP_HMZ worflows.
- Calculation of the pathogencity now accounts for using the lowest number after aggregating the variant impact scores.
- Hide sort columns feature in the Classifications page.
v4 Pilot Calculator UI
update
Workflow Update
2.2.14
2025-09-30
- Informative variant workflows updated for canonical and non-canonical splice assessment.
- CLN_ALT gene and variant point calculation fixed
- Text updated for exon deletion workflows
- First variant input option for the comparison variant workflows updated to allow 0 or 1 entries
v4 Pilot Calculator UI
bug-fix
Workflow Update
2.2.13
2025-09-30
- Save feature fixed for clinical observations workflow, CLN_DNV.
v4 Pilot Calculator UI
update
Workflow Update
2.2.7
2025-09-30
- Comparison variants workflows for the Start-Loss variant type are updated
- Required properties for saving a document are changed to be just CAid and affiliation ID.
- Marking the classification Complete will require - CAid, affiliation ID, gene and disease entities.
v4 Pilot Calculator UI
new-feature
Several new features and bug fixes
2.2.5
2025-09-22
- Menu bar updated
- Bug fix for SPL_SPA workfows
- Change status button updated to be a toggle
v4 Pilot Calculator UI
new-feature
Several new features.
2.2.4
2025-09-15
- Menu bar updated
- Prompt calculate points workflows
- Save feature fixed for Predicted and Functional Data
v4 Pilot Calculator UI
new-feature
Several new features.
2.2.1
2025-09-10
- Document states to track completion of a classification
- Codes changed - to support saving splice workflows
- Fixed classification point scale
- Fixed PFD data for synonymous variants
- Workflow for Locus Specificity modified to include two steps
- Features to expand and collapse workflows
v4 Pilot Calculator UI
new-feature
Several new features added as path specific Molecular Mechanism scoring, etc.
2.1.12
2025-08-22
- Codes changed
- Save feature restored
- HGVS modified to have c. and p.
- Fixed HOD data
v4 Pilot Calculator UI
new-feature
Several new features added as path specific Molecular Mechanism scoring, etc.
2.1.11
2025-08-19
- Codes changed
- Overhauled the calculator
- Evidence Codes changed, new functional and predicted data
- Reset fixed
v4 Pilot Calculator UI
new-feature
Several new features added as path specific Molecular Mechanism scoring, etc.
2.1.7
2025-08-14
- Codes changed
- Overhauled the calculator
- Evidence Codes changed, new functional and predicted data
- Reset fixed
v4 Pilot Calculator UI
new-feature
Several new features added as path specific Molecular Mechanism scoring, etc.
1.0.2
2025-04-30
- Codes changed
- Bug fixes in calculation and loading
- Changes based on the initial pilot feedback
v4 Pilot Calculator UI
bug-fix
Fixed the classification page loading by correcting the affiliation content parsing
1.0.1
2025-04-11
v4 Pilot Calculator UI
new-feature
Initial launch of the v4 Pilot Calculator
1.0.0
2025-04-10