All Allele Registry Extension APIs News

Allele Registry Extension APIs

update

Purge miscellaneous indexes from car extension's database collections.

8.22.1

2026-09-08

Update @brl/cg-car-lib for script that removes miscellaneous indexes from car extension's database collections.

Allele Registry Extension APIs

update

Improve AQL error logging, end-to-end error messages, and interval sync thread adb checks and logging.

8.22.2

2026-09-03

Update @brl/cg-car-lib to add detailed AQL query logging for specific errors and improve ArangoDB checks in the interval sync thread.
Improve end-to-end error reporting for loc-reg, sv-reg, ht-reg, hla-reg, and pgx-reg.

Allele Registry Extension APIs

fix

Fix several mistakes found from cgbuilder deploy.

8.19.25

2026-09-02

Propagate Node activation and auth registration failures directly through the deployment migrations for all CAR registries.
Source .bashrc file in auth context migrations.
Skip node v22 pm2 env checks in migration script when the service is not running under pm2.
Fix ht-reg's env template it was missing HT_SRVC_PORT variable.
Fix end-to-end tests for overlapping routes. Pick a range that should overlap with sv and loc descriptors that are already in the registry.
Fix incorrect loc-reg exposed mount which was /allele when it should have been /reg and ns prefix from CALO to GL.
Fix reuse of the same object reference across tap.test() calls. Each test now explicitly declares its own options or receives a copy of the options object. This change exposed several issues in the pgx-reg end-to-end tests, which were also addressed.
Update loc-reg test fixtures. Both precise and imprecise coordinates are supported, e.g. NCBI36 (chrX:46951229-47768540_?).
Ensure node_modules/ is reinstalled at least once for both sv-reg and loc-reg after a potential Node.js upgrade from v20 to v22. Both services depend on SQLite for synchronizing intervals used in range queries.
Fix overlapping range validation for chrMT.

Allele Registry Extension APIs

feature

Add brl-cgbuilder deploy support

8.19.11

2026-06-18

Add a new brl-cgbuilder deploy environment for the builder team.

Allele Registry Extension APIs

feature

Add faster overlap queries

8.19.8

2026-06-03

Added interval collections to improve overlap query performance in sv-reg and loc-reg.
Added computed created and modified values to registry collections.
Improved sv-reg descriptor search performance.
Fixed imprecise coordinate handling when sv-reg and loc-reg build descriptors from CAR-transformed coordinates.
Fixed ht-reg concurrency synchronization between registration and admin write queries.
Ensured all registries run consistently under Node.js v22.
Fixed deployed registry DATA_AREA env values to use the deploy-tools data area plus fully qualified service name.

Allele Registry Extension APIs

fix

Fixed Coordinate Transform Logic

8.16.3

2026-02-16

Fixed coordinate transform logic for cases where CAR doesn't include the originally provided coordinates, but includes lifted coordinates to alternative assemblies.

Allele Registry Extension APIs

feature

Code update

8.16.0

2026-02-11

Updated dependencies to use latest fastify version.

Allele Registry Extension APIs

feature

SV prefix search

8.15.1

2026-02-06

Added SV prefix search endpoint GET /sv/desc?search=grch38.
Added HT repair script to repair haplotype registrations where not all edges were created.
Fixed overlapping count endpoint for sv-reg, loc-reg, and ht-reg to return correct count by using same max limit as overlapping endpoint.

Allele Registry Extension APIs

feature

License and Terms of Use service endpoints

8.14.0

2025-12-30

Added License and Terms of Use plugins.

Allele Registry Extension APIs

feature

Add Haplotype Registry and various features to CAR extension services.

8.13.0

2025-12-30

Added Haplotype Registry.
Added GET /desc/:desc/normalized and POST /desc/normalized routes to all car extension services.
Added GET /mq/sse/evts/requests for event source of requests made to a car extension services.
Added POST /mq/sse/evts/reg to produce reg events.
Added asymmetric coordinate support to SV and GL registry. This allows registration of descriptors with a mix of precise and imprecise coordinates.
Added SV type filter support to GET /sv/desc/:desc/overlapping with the ?types query parameter.
Added prefix search for PGX alleles .e.g. GET /pgx/id/?search=NUDT.
Added count endpoint to to all sv-reg, loc-reg, and ht-reg overlap endpoints e.g. GET /sv/desc/:desc/overlapping/count.
Enable toggle of CORS for cases where reverse proxy already handles it.

Allele Registry Extension APIs

feature

Add prefix search for HLA descriptors.

8.1.3

2025-06-09

Added prefix search for HLA allele descriptors.
Fixed subtle bug preventing SSEs from being emitted caused by mis-management of queue for requests.

Allele Registry Extension APIs

feature

Add PGX Registry

8.0.0

2025-04-24

Add Cligen PGX Registry.
Change HLA namespace from CAHLA to XAHLA.

Allele Registry Extension APIs

fix

Fix loc-reg duplicates

N/A

2025-03-21

Fixed loc-reg duplicates.
Deployed to cloud VMs.

Allele Registry Extension APIs

fix

Fixed Descriptor Registration Logic

6.10.0

2025-03-11

Fixed the descriptor registration logic for aber, sv, and loc services to prevent duplicate registration.
Unified single and batch descriptor transform.
Improved error logging.

Allele Registry Extension APIs

feature

Added support for batch descriptor registration.

6.8.2

2025-02-05

Sv, Aber, Loc, and HLA descriptors can now be registered in batches and concurrently.
Enforced 1-based fully closed range validation for Sv and Loc descriptors.
Fixed format of logged errors.
Improved error response messages.
Improved handling of network errors from AR service.

Allele Registry Extension APIs

feature

Support GET /$/*, GET /?fields, and GET /id/ for all services.

6.5.1

2024-10-17

Allele Registry Extension APIs

fix

Improve request client error handling and descriptor normalization

6.4.0

2024-10-11

Fixed max retry, base sleep, and timeout request client issues and made them configurable.
Fixed descriptor normalization of chrM to chrMT.

Allele Registry Extension APIs

feature

Use Independent Coordinate Transform

6.3.1

2024-09-19

Remove database transaction queries.
Add concurrency handling for parallel descriptor registration for improved service robustness and data integrity.

Allele Registry Extension APIs

fix

Fix Descriptor Registration AQL Logic

6.0.17

2024-07-01

Allele Registry Extension APIs

feature

Add HLA Registry

6.0.11

2024-05-28

Allele Registry Extension APIs

feature

Add Count Summary

5.2.1

2024-04-01

Added count summary to sv, ab, and gl service's GET /srvc routes.

Allele Registry Extension APIs

feature

Deploy SV, AB, and GL Registries.

5.0.5

2024-02-26

Deployed Genomic Structural Variant Registry.
Deployed Genomic Aberration Registry.
Deployed Genomic Location Registry.