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[[_TOC_]]
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### Assertion API
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Assertion API endpoint for computing variant pathogenicity given a set of evidence counts and the specification to use. The specification used here is based on _Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology_. Richards _et.al_ (https://pubmed.ncbi.nlm.nih.gov/25741868/). For ClinGen VCEP specific assertion criteria refer the CSpec Registry - https://cspec.genome.network
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**Summary of Sequence Variant Interpretation Reasoner service route which interprets a variant pathogenicity assertion from Evidence and [Criteria Specification](https://cspec.genome.network)**
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