{
  "jsonMessageVersion" : "2.0.0",
  "statusPublishFlag" : "Publish",
  "type" : "actionability",
  "affiliations" : [
    {
      "id" : "Pediatric AWG",
      "name" : "Pediatric Actionability Working Group"
    }
  ],

  "iri" : "https://10.15.55.128/ac/Pediatric/api/sepio/doc/AC001",
  "title" : "Retinoblastoma - RB1",
  "curationVersion" : "1.3.4",
  "curationType" : "Gene-Condition",
  "statusFlag" : "Released",
  "dateISO8601" : "2022-02-09T00:00:00-06:00",
  "releaseNotes" : "Internal system migration associated with MONDO name addition.",
  "surveyDetails" : "https://10.15.55.128/ac/ui/stg1RuleOutRpt?doc=AC001",
  "earlyRuleOutStatus" : "Complete",
  "scoreDetails" : "https://10.15.55.128/ac/Pediatric/ui/stg2SummaryRpt?doc=AC001",
    "genes" : [
      {
      "symbol" : "RB1",
      "ontology" : "HGNC",
      "curie" : "HGNC:9884",
      "uri" : "HGNC9884"
    }
    ],
    "preferred_conditions" : [
      {
  "ontology" : "MONDO",
  "curie" : "MONDO:0008380",
  "uri" : "MONDO0008380",
  "iri" : "http://purl.obolibrary.org/obo/MONDO_0008380",
  "gene" : "HGNC:9884"
}
    ],
    "conditions" : [
        {
      "ontology" : "MONDO",
      "curie" : "MONDO:0008380",
      "uri" : "MONDO0008380",
      "iri" : "http://purl.obolibrary.org/obo/MONDO_0008380",
      "gene" : "HGNC:9884"
    }
    ],
   "assertions" : [
       {
      "ontology" : "MONDO",
      "curie" : "MONDO:0008380",
      "uri" : "MONDO0008380",
      "iri" : "http://purl.obolibrary.org/obo/MONDO_0008380",
      "gene" : "HGNC:9884",
      "assertion" : "Strong Actionability"
    }
   ],
  "scores" : [
      {
      "Outcome" : "Morbidity or mortality from retinoblastoma",
      "ScoringGroups" : [
        {
          "ScoringGroup" : [{"geneOmim":"614041","disOmim":"180200","gene":"RB1","preferredMondo":"0008380"}],
          "Severity" : "2",
          "Likelihood" : "3C",
          "Interventions" : [
            {
              "Intervention" : "Surveillance",
              "ScoringGroups" : [
                {
                  "ScoringGroup" : [{"geneOmim":"614041","disOmim":"180200","gene":"RB1","preferredMondo":"0008380"}],
                  "Effectiveness" : "3B",
                  "Nature of Intervention" : "2",
                  "Total" : "10CB"
                }
              ]
            }
          ]
        }
      ]
    },
    {
      "Outcome" : "Morbidity or mortality from second extra-ocular malignant neoplasms",
      "ScoringGroups" : [
        {
          "ScoringGroup" : [{"geneOmim":"614041","disOmim":"180200","gene":"RB1","preferredMondo":"0008380"}],
          "Severity" : "2",
          "Likelihood" : "2C",
          "Interventions" : [
            {
              "Intervention" : "Surveillance",
              "ScoringGroups" : [
                {
                  "ScoringGroup" : [{"geneOmim":"614041","disOmim":"180200","gene":"RB1","preferredMondo":"0008380"}],
                  "Effectiveness" : "2N",
                  "Nature of Intervention" : "3",
                  "Total" : "9CN"
                }
              ]
            }
          ]
        }
      ]
    }
  ],
  "assertions" : [
    
  ],
  "searchDates" : [
    "2018-04-30T00:00:00Z"
  ]
}